piyumali's articles

  1. Department Of Biomedical Science
Abstract Background: Gastric cancer is the second leading cause of cancer-related mortality and the fourth most common cancer globally. This study was conducted to evaluate the usefulness of miR-21 as a less invasive screening and prognostic marker in Gastric cancer patients from Sri Lanka. Further the H. pylori status was investigated. Methods: Twenty patients who […]
  1. Department Of Biomedical Science
https://doi.org/ 10.15171/ijep.2016.12 Abstract Background: Helicobacter pylori has been identified as a group I carcinogenic bacterium that infects the gastric mucosa leading to gastritis, peptic ulcer disease, lymphoma, and gastric cancer. Pathogenesis of H. pylori depends on the virulence of the strain, host immune response, and modulating factors like smoking and diet. Objectives: This study aimed […]
  1. Department Of Biomedical Science
https://doi.org/10.1155/2017/6265150 Abstract Background. The pro-and anti-inflammatory cytokines play an important role in the immune response against H. pylori infection. The proinflammatory cytokines of Th17 cells have been suggested to play a major role in H. pylori infection and resulting gastric inflammation. Objective. The objective of this study was to compare the expression of selected inflammatory […]
  1. Department Of Biomedical Science
https://doi.org/10.20959/wjpr20185-11214 ABSTRACT Objective: This study was aimed to assess the usefulness of Gastropanel assay, an ELISA-based non-invasive diagnostic technique, in diagnosis of H. pylori infection and disease severity in a Sri Lankan population. Methods: Blood specimens were collected from dyspeptic patients attending routine upper-gastrointestinal endoscopy at a tertiary care hospital. Serum Gastrin-17, Pepsinogen I and […]
  1. Department Of Biomedical Science
https://doi.org/10.1111/1348-0421.12597 ABSTRACT Single nucleotide polymorphisms present on the promoter sequence of the TNF-a gene may affect production of TNF-a, a pro-inflammatory cytokine,during immune responses. The presence of TNF-a polymorphisms is also reportedly associated with more severe manifestations of Helicobacter pylori infection. However, the frequency of TNF-a polymorphisms and the associated disease severity vary between different […]
  1. Department Of Biomedical Science
https://doi.org/10.1186/s13104-018-3592-2 Abstract Objective: The study aimed to compare the usefulness of two staining methods for imprint cytology for diagnosis of Helicobacter pylori infection. Gastric biopsy specimens (from dyspeptic patients attending routine upper gastrointestinal endoscopy) were placed on glass slides to obtain imprints. The imprints were stained with Toluidine blue and Giemsa stains separately and observed […]

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