Background. The pro-and anti-inﬂammatory cytokines play an important role in the immune response against H. pylori infection. The proinﬂammatory cytokines of Th17 cells have been suggested to play a major role in H. pylori infection and resulting gastric inﬂammation.
Objective. The objective of this study was to compare the expression of selected inﬂammatory cytokines (IL-10, IL-17, IL-21, IL-23, and TNF-α) in H. pylori-infected patients and healthy controls and to understand their association with H. pylori infection and disease severity.
Results. The expression levels of IL-17 and IL-23 were signiﬁcantly higher in H. pylori infected patients. The expression of IL-21 was also higher in H. pylori-positive patients but there was no signiﬁcant association with infection. IL-17 expression showed a signiﬁcant increase with the severity of chronic gastritis.
Conclusion. The proinﬂammatory cytokine, IL-17, shows a signiﬁcant association with H. pylori infection and disease severity in a Sri Lankan dyspeptic patient population.